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Chiba University Scientists Introduce Pioneering Method For Ultra-Fast Microdroplet Production In Microfluidic Devices

Science News

Breakthrough in Microfluidics: Revolutionizing Droplet Production with New Technique

Chiba University Researchers Unveil Novel Method in Lab on a Chip

In a groundbreaking study published in the January 21, 2024 issue of “Lab on a Chip,” scientists from Chiba University introduced a pioneering method for ultra-fast microdroplet production in microfluidic devices.

Developed by Associate Professor Masumi Yamada and first author Shota Mashiyama from the Department of Applied Chemistry and Biotechnology at the Graduate School of Engineering, moreoover, utilizes three-dimensional porous “inverse colloidal crystal” (ICC) structures to significantly enhance the efficiency of droplet generation.

Overcoming Limitations in Microfluidic Applications

In another recent groundbreaking study, National Institute of Standards and Technology researchers have combined a glass slide, plastic sheets and double-sided tape to create an inexpensive and simple-to-build microfluidic device for exposing an array of cells to different concentrations of a chemical.

Microfluidic devices, crucial in fields ranging from medicine to semiconductor manufacturing, have traditionally been hampered by slow droplet production rates. This limitation has restricted their application in various domains, including chemical reactions, biomolecular analysis, and soft-matter chemistry. The Chiba University team’s research marks a significant leap in addressing this challenge, paving the way for more efficient production and broader application scopes.

The Power of ICC Structures in Microfluidics

The novel technique involves integrating spongy ICC structures with flat microchannels, effectively functioning as minuscule nozzles. This integration results in droplet production speeds approximately 1,000 times faster than conventional methods. Moreover, the method allows for control over droplet size by adjusting liquid flows, their properties, and the size of the microchannel openings. This versatility extends to the production of single micrometer-sized particles made from natural biopolymers like polysaccharides and proteins.

A Versatile Method with Broad Impact


The implications of this advanced method are far-reaching. It promises to revolutionize a range of industries, including medicine, food, cosmetics, specialized inks, paints, bioseparation matrices, and the manufacturing of functional particles for display and semiconductor applications. The ability to efficiently produce microdroplets, biopolymer particles, and vesicles holds particular promise for medical applications such as drug development, regenerative medicine, and cellular immunotherapy.

Dr. Yamada envisions the method being used for various purposes, including drug delivery carriers, cell culture scaffolds, cell transformation reagents, antigen carriers in cellular immunotherapy, and functional microparticles for diagnostics. The advancement in droplet microfluidics is not just about increased speed; it also simplifies the creation and operation processes, making it more accessible and practical for various applications.

Enhancing Lives and Well-being Through Advanced Technology

The integration of three-dimensional ICC structures into traditional microfluidic channels marks a significant stride in microfluidic technology. By enabling the rapid formation of droplets at unprecedented speeds, this method opens up new possibilities for producing materials that can improve people’s lives and support overall well-being. The Chiba University team’s innovation stands as a testament to the evolving landscape of technology and its potential to drive forward industries and healthcare.

Journal: Lab on a Chip


Chiba University